How many MPG does a 2025 Mercedes-Benz E350 get?

The 2025 Mercedes-Benz E350 gets 28 MPG combined according to the EPA — about 25 MPG in the city and 33 MPG on the highway. Combined MPG is a 55% city / 45% highway blend.

What is the annual fuel cost for a 2025 Mercedes-Benz E350?

Driving 15,000 miles a year at 28 MPG combined, the 2025 Mercedes-Benz E350 uses about 536 gallons of fuel per year — roughly $1,876 at $3.50/gallon. Your real cost varies with local gas prices and driving style.

What is the difference between city and highway MPG on the 2025 Mercedes-Benz E350?

The 2025 Mercedes-Benz E350 returns 25 MPG city and 33 MPG highway. Highway is higher because steady-speed cruising avoids the stop-and-go acceleration that burns fuel in city driving. The 28 MPG combined figure blends the two.

Is 28 MPG good for a midsize cars?

For a midsize cars, 28 MPG combined is about average. Hybrid trims and smaller engines, where offered, return better numbers.

2025 Mercedes-Benz E350 MPG

Official EPA fuel-economy rating for the 2025 Mercedes-Benz E350.

EPA combined fuel economy

28MPG

combined (55% city / 45% hwy)

City

MPG

Highway

MPG

Engine

Cylinders

Drive

RearWD

Class

Midsize Cars

Running cost

Estimated annual fuel cost

Per year

$1,876

15,000 mi/yr

Fuel used

536 gal

per year

At gas price

$3.50

per gallon

Based on 28 MPG combined and 15,000 miles per year. Adjust for your local gas price and annual mileage.

Other Mercedes-Benz E350 years

2026 2023 2022 2021 All years →

FAQ

2025 Mercedes-Benz E350

How many MPG does a 2025 Mercedes-Benz E350 get?: The 2025 Mercedes-Benz E350 gets 28 MPG combined according to the EPA — about 25 MPG in the city and 33 MPG on the highway. Combined MPG is a 55% city / 45% highway blend.
What is the annual fuel cost for a 2025 Mercedes-Benz E350?: Driving 15,000 miles a year at 28 MPG combined, the 2025 Mercedes-Benz E350 uses about 536 gallons of fuel per year — roughly $1,876 at $3.50/gallon. Your real cost varies with local gas prices and driving style.
What is the difference between city and highway MPG on the 2025 Mercedes-Benz E350?: The 2025 Mercedes-Benz E350 returns 25 MPG city and 33 MPG highway. Highway is higher because steady-speed cruising avoids the stop-and-go acceleration that burns fuel in city driving. The 28 MPG combined figure blends the two.
Is 28 MPG good for a midsize cars?: For a midsize cars, 28 MPG combined is about average. Hybrid trims and smaller engines, where offered, return better numbers.