Mercedes-Benz E350 MPG by year

EPA combined, city, and highway gas mileage for every Mercedes-Benz E350 model year.

Year	Combined	City	Highway
2026	28	25	33
2025	28	25	33
2023	26	23	31
2022	26	23	31
2021	25	22	31
2020	26	23	32
2016	23	20	28
2015	22–23	20	28
2014	22–24	20	29
2013	22–23	20	28
2012	22–23	19	28
2011	20	17	25
2010	20–21	18	26