How many MPG does a 2022 Mercedes-Benz S500 4matic get?

The 2022 Mercedes-Benz S500 4matic gets 24 MPG combined according to the EPA — about 21 MPG in the city and 30 MPG on the highway. Combined MPG is a 55% city / 45% highway blend.

What is the annual fuel cost for a 2022 Mercedes-Benz S500 4matic?

Driving 15,000 miles a year at 24 MPG combined, the 2022 Mercedes-Benz S500 4matic uses about 625 gallons of fuel per year — roughly $2,188 at $3.50/gallon. Your real cost varies with local gas prices and driving style.

What is the difference between city and highway MPG on the 2022 Mercedes-Benz S500 4matic?

The 2022 Mercedes-Benz S500 4matic returns 21 MPG city and 30 MPG highway. Highway is higher because steady-speed cruising avoids the stop-and-go acceleration that burns fuel in city driving. The 24 MPG combined figure blends the two.

Is 24 MPG good for a large cars?

For a large cars, 24 MPG combined is about average. Hybrid trims and smaller engines, where offered, return better numbers.

2022 Mercedes-Benz S500 4matic MPG

Official EPA fuel-economy rating for the 2022 Mercedes-Benz S500 4matic.

EPA combined fuel economy

24MPG

combined (55% city / 45% hwy)

City

MPG

Highway

MPG

Engine

Cylinders

Drive

AllWD

Class

Large Cars

Running cost

Estimated annual fuel cost

Per year

$2,188

15,000 mi/yr

Fuel used

625 gal

per year

At gas price

$3.50

per gallon

Based on 24 MPG combined and 15,000 miles per year. Adjust for your local gas price and annual mileage.

Other Mercedes-Benz S500 4matic years

2026 2025 2024 2023 2021 All years →

FAQ

2022 Mercedes-Benz S500 4matic

How many MPG does a 2022 Mercedes-Benz S500 4matic get?: The 2022 Mercedes-Benz S500 4matic gets 24 MPG combined according to the EPA — about 21 MPG in the city and 30 MPG on the highway. Combined MPG is a 55% city / 45% highway blend.
What is the annual fuel cost for a 2022 Mercedes-Benz S500 4matic?: Driving 15,000 miles a year at 24 MPG combined, the 2022 Mercedes-Benz S500 4matic uses about 625 gallons of fuel per year — roughly $2,188 at $3.50/gallon. Your real cost varies with local gas prices and driving style.
What is the difference between city and highway MPG on the 2022 Mercedes-Benz S500 4matic?: The 2022 Mercedes-Benz S500 4matic returns 21 MPG city and 30 MPG highway. Highway is higher because steady-speed cruising avoids the stop-and-go acceleration that burns fuel in city driving. The 24 MPG combined figure blends the two.
Is 24 MPG good for a large cars?: For a large cars, 24 MPG combined is about average. Hybrid trims and smaller engines, where offered, return better numbers.