Mercedes-Benz E450 4matic MPG by year

EPA combined, city, and highway gas mileage for every Mercedes-Benz E450 4matic model year.

Year	Combined	City	Highway
2026	25	22	31
2025	25	22	31
2024	25	22	31
2023	24–26	22	30
2022	24–25	22	30
2021	25–26	23	30
2020	22–23	19	26
2019	22–23	19	26