Mercedes-Benz E350 4matic MPG by year

EPA combined, city, and highway gas mileage for every Mercedes-Benz E350 4matic model year.

Year	Combined	City	Highway
2026	27	24	33
2025	27	24	33
2024	27	24	33
2023	24	21	30
2022	24	21	29
2021	25	22	30
2020	25	22	30
2016	22–23	20	27
2015	22–23	20	27
2014	22–23	20	27
2013	22	19	28
2012	22	19	27
2011	19	16	24
2010	19	17	24